期刊
BIOCONJUGATE CHEMISTRY
卷 19, 期 1, 页码 5-9出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc700267f
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- NATIONAL EYE INSTITUTE [T32EY013933] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM036564] Funding Source: NIH RePORTER
- NEI NIH HHS [EY 013933] Funding Source: Medline
- NIGMS NIH HHS [GM 36564] Funding Source: Medline
Porphyrinmaleimides were synthesized and characterized. The thiol-containing amino acid L-Cysteine reacted with 58% yield with these porphyrins to form bioconjugate adducts. The new thiol-active reagents were labeled cytoplasmic cysteine 140 and 316 in rhodopsin (Rh), a G protein coupled receptor (GPCR).
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