4.6 Article

Phase I trial of HuM291, a humanized anti-CD3 antibody, in patients receiving renal allografts from living donors

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TRANSPLANTATION
卷 70, 期 12, 页码 1707-1712

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00007890-200012270-00008

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Background. HuM291 is a humanized anti-CD8 monoclonal antibody engineered to reduce binding to Fc gamma receptors and complement fixation, HuM291 has a long serum half-life and mediated profound depletion of circulating T cells in chimpanzees; HuM291 also has significantly less mitogenic and cytokine-releasing activity than OKT3 in vitro. Methods. A phase I dose-escalation study was conducted in 15 end-stage renal disease patients scheduled for renal allografts from living donors, Patients received one i,v, HuM291 injection before transplanta- tion, Five doses were tested: 0.015 mug/kg, 0.15 mug/kg, 0.0015 mg/kg, 0.0045 mg/kg, and 0.015 mg/kg, Patients were followed for adverse events, laboratory abnormalities, serum cytokine levels, pharmacokinetics, and CD2(+), CD3(+), CD4(+), and CD8(+) T cell counts. Results. HuM291 was well tolerated; most adverse events were mild to moderate in severity and included headache, nausea, chills, and fever. These occurred within the first few hours after HuM291 administration, resolved within 24 to 48 hr, and were likely related to cytokine release. In general, peak tumor necrosis factor-alpha, interferon-gamma, and interleukin-g levels were detected 1 to 6 hr postdosing only at the three highest doses and were generally undetectable by 24-hr postdosing, Serious adverse events possibly related to HuM291 included clotting of a fistula (two patients), chemical cellulitis tone patient), and increased serum creatinine/decreased hematocrit tone patient). At doses greater than or equal to0.0015 mg/kg (0.1 mg/70 kg), HuM291 induced rapid, marked depletion of peripheral T cells within 2 hr; duration of T cell depletion was dose dependent. At the two highest dose levels, T cells remained depleted for approximately 1 week. Conclusions. A single HuM291 dose rapidly depleted circulating T cells in a dose-dependent manner and was associated with only mild to moderate symptoms of cytokine release.

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