期刊
BIOCONJUGATE CHEMISTRY
卷 19, 期 11, 页码 2231-2238出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc800090v
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资金
- Bayer Canadian Blood Services Hema-Quebec Partnership [1614230, 1664725, 1721923]
- Canadian Institutes of Health Research
- Natural Science and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Canadian Blood Services
- Michael Smith Foundation for Health Research
- BC Knowledge Development Fund
We recently reported the synthesis and testing of a new class of unimolecular micelles based on hyperbranched polyglycerols as second generation synthetic plasma expanders and as general drug delivery vehicles. A detailed biodistribution study of two derivatized hyperbranched polyglycerols of different molecular weights derivatized with hydrophobic groups and short poly(ethylene glycol) chains is reported in this article. In mice, these materials are nontoxic with circulation half-lives as high as 31 h, controllable by manipulating the molecular weight and the degree of PEG derivatization. Organ accumulation is low, presumably due to the pegylation effect. Thermal degradation and hydrolysis data suggest that these polymers are highly stable with a long shelf life, a major advantage for a pharmaceutical product. Degradation under acidic conditions has been observed for these polymers.
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