期刊
BIOCHIP JOURNAL
卷 6, 期 2, 页码 114-119出版社
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-012-6202-8
关键词
Gentiana scabra (GS); Glucagon-like peptide-1 (GLP-1); NCI-H716; Type II diabetes mellitus; Herbal medicine
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-00071 06]
- Undergraduate Research Program (URP) grant
- Kyung Hee University College of Oriental Medicine
- grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea [B1000 34]
- Korea Foundation for the Advancement of Science Creativity
Glucagon-like peptide-1 (GLP-1) which secreted by enteroendocrine L cell have been issued as a therapeutic agent for type II diabetes mellitus, because of its function to stimulate insulin secretion in pancreatic beta-cells. It is widely studied that sweet, bitter, and umami taste stimuli induce the secretion of GLP-1 in enteroendocrine L cell via G protein coupled receptor (GPCR) signaling pathway. Gentiana scabra (GS) is one of the bitter tasting herbal medicines which have been used in traditional oriental medicine to treat the diabetes mellitus. This study shows the GLP-1 secretion of the enteroendocrine L cell stimulated by stimulation of GS extractions through GPCR pathway. To examine the molecular mode-of-action, GLP-1 ELISA and microarray was performed. This study provides the understanding the possibility of GS used as a therapeutic herbal medicine for the type II diabetes.
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