期刊
VIROLOGY
卷 279, 期 1, 页码 339-342出版社
ACADEMIC PRESS INC
DOI: 10.1006/viro.2000.0700
关键词
simian varicella virus; monkey ganglia; varicella zoster virus
类别
资金
- NIA NIH HHS [AG 06127] Funding Source: Medline
- NINDS NIH HHS [NS07321, NS 32623] Funding Source: Medline
Monkeys experimentally infected with simian varicella virus (SW) develop rash 10-14 days later. However, the route and the time of ganglionic infection are unknown. Using PCR, we analyzed DNA extracted from tissues of 13 monkeys 5 to 60 days after either intratracheal or intravenous inoculation with SW. SW DNA was detected in gsnglia from four of five monkeys sacrificed 6 to 7 days after intratracheal inoculation. Further, analysis of ganglia from monkeys sacrificed at 10 days revealed that intravenous inoculation produced a higher proportion of SW DNA-positive gang[ia (63%) than that after intratracheal inoculation (13%), pointing to the role of hematogenous spread in ganglionic infection. Like other organs, monkey ganglia become infected with SW before the appearance of rash. (C) 2001 Academic Press.
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