期刊
ORGANIC LETTERS
卷 3, 期 1, 页码 57-59出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol006767d
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资金
- NCI NIH HHS [2 R01-CA 66736] Funding Source: Medline
[GRAPHICS] We describe a semi-synthetic deglycosylated derivative of apoptolidin that retains considerable activity against the mitochondrial ATPase but has greatly reduced cellular cytotoxicity. We also demonstrate that a related antifungal natural product, cytovaricin, inhibits the same molecular target. Structural comparison of these macrolides provides insights into their conserved features that are presumably important for biological activity and identifies promising avenues at the interface of organic synthesis and biosynthesis for the generation of new selective cytotoxic agents.
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