期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 193, 期 2, 页码 219-231出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.193.2.219
关键词
interleukin 15; leukemia; transgenic mice; lymphocytes; inflammation
Inflammation likely has a role in the early genesis of certain malignancies. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms. Here, we engineered a transgenic mouse to overexpress IL-15 by eliminating these posttranscriptional checkpoints. IL-15 transgenic mice have early expansions in natural killer (NK) and CD8(+) T lymphocytes. Later, these mice develop fatal lymphocytic leukemia with a T-NK phenotype. These data provide novel evidence that leukemia, like certain other cancers, can arise as the result of chronic stimulation by a proinflammatory cytokine.
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