期刊
BIOLOGICAL PSYCHIATRY
卷 49, 期 2, 页码 81-96出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)01038-6
关键词
positron emission tomography (PET); dopamine; mesolimbic; striatum; accumbens
资金
- NCRR NIH HHS [RR00056] Funding Source: Medline
- NIMH NIH HHS [MH01713] Funding Source: Medline
Background: Studies in experimental animals have implicated the mesolimbic dopaminergic projections into the ventral striatum in the neural processes underlying behavioral reinforcement and motivated behavior; however, understanding the relationship between subjective emotional experience and ventral striatal dopamine (DA) release has awaited human studies. Using positron emission tomography (PET), we correlated the change in endogenous dopamine concentrations following dextroamphetamine (AMPH) administration with the associated hedonic response in human subjects and compared the strength of this correlation across striatal subregions, Methods: We obtained PET measures of [C-11]raclopride specific binding to DA D2/D3 receptors before and after AMPH injection (0.3 mg/kg IV) in seven healthy subjects. The change in [C-11]raclopride binding potential (Delta BP) induced by AMPH pretreatment and the correlation between Delta BP and the euphoric response to AMPH were compared between the anteroventral striatum (AVS; comprised of accumbens area, ventromedial caudate, and anteroventral putamen) and the dorsal caudate (DCA) using an MRI-based region of interest analysis of the PET data. Results: The mean Delta BP was greater in the AVS than in the DCA (p < .05). The AMPH-induced changes in euphoria analog scale scores correlated inversely with BP in the AVS (r = -.95; p < .001), but not in the DCA (r = .30, ns). Post hoc assessments showed that changes in tension-anxiety ratings correlated positively with BP in the AVS (r = .80; p [uncorrected] < .05) and that similar relationships may exist between BP and emotion ratings in the ventral putamen (as were found in the AVS), Conclusions: The preferential sensitivity of the ventral striatum to the DA releasing effects of AMPH previously demonstrated in experimental animals extends to humans. The magnitude of ventral striatal DA release correlates positively with the hedonic response to AMPH. (C) 2001 Society of Biological Psychiatry.
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