期刊
IMMUNOLOGY LETTERS
卷 75, 期 3, 页码 191-197出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(00)00310-2
关键词
interferon-beta; multiple sclerosis; serum amyloid A protein; C-reactive protein; mononuclear leukocytes
类别
Putative markers of inflammation such as serum beta2-microglobulin and neopterin have been shown to be transiently upregulated following interferon-beta (IFN-beta) administration to multiple sclerosis (MS) patients. However, to date the role of the important inflammatory mediators serum amyloid A protein (SAA) and C-reactive protein (CRP) have not been described. Here we show that SAA but not CRP is elevated in relapsing-remitting MS patients compared to normal healthy individuals; and furthermore that both are transiently upregulated following intramuscular injection with IFN-beta 1a (Avonex(TM)). This pattern of expression was found to parallel that of beta2-microglobulin and neopterin following injection and was mirrored by a selective activation of peripheral monocytes with respect to upregulation of receptors known to be involved in the inflammatory response (HLA-DR, CD16 and CD86). Injection of saline solution intramuscularly to six healthy control individuals did not produce a similar upregulation of any of the inflammatory markers investigated. Following IFN-beta 1a injection, all inflammatory responses were attenuated at week 12 of therapy in comparison to those following the initial injection in a group of follow-up patients. In addition, IFN-beta 1a injected on a weekly basis did not produce a sustained modulation of any of the markers investigated in patients treated for 32 weeks. (C) 2001 Elsevier Science B.V. All rights reserved.
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