期刊
NUCLEIC ACIDS RESEARCH
卷 29, 期 2, 页码 351-361出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/29.2.351
关键词
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资金
- Wellcome Trust Funding Source: Medline
The distribution of optimal local alignment scores of random sequences plays a vital role in evaluating the statistical significance of sequence alignments, These scores can be well described by an extreme-value distribution. The distribution's parameters depend upon the scoring system employed and the random letter frequencies; in general they cannot be derived analytically, but must be estimated by curve fitting. For obtaining accurate parameter estimates, a form of the recently described 'island' method has several advantages. We describe this method in detail, and use it to investigate the functional dependence of these parameters on finite-length edge effects.
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