期刊
BIOCHIMIE
卷 95, 期 7, 页码 1506-1509出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2013.04.009
关键词
Alzheimer's disease; Presenilin-1; STIM2; Isoc; Icrac; Whole-cell recording
资金
- RAS
- RFBR
- EraNet-RUS
- OPTEC LLC
- Russian Federation Fellowship
Alzheimer's disease (AD) is a neurodegenerative disorder that leads to neuron death and synapse loss in the hippocampus and cortex, with consequent cognitive disability and dementia. Mutations in the presenilin-1 (PSI) gene lead to familial Alzheimer's disease (FAD). Here, we report that the expression of FAD-linked PSI M146V mutant affects store-operated calcium channel activity (Isoc) in human neuroblastoma SK-N-SH cells. Electrophysiological measurements and calcium imaging experiments have revealed the emergent role of calcium sensor STIM2 in the inhibition of calcium release-activated calcium channel activity (Icrac) and enhancement of intracellular Ca2+ stores content due to PS1 M146V mutant expression. In general, the results of this study suggest that the pathological inhibition of one type of store-operated calcium channels caused by FAD PSI mutant expression may be accounted for by preceding gain of spontaneous activity of store-operated calcium channels driven by STIM2. (C) 2013 Elsevier Masson SAS. All rights reserved.
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