期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 193, 期 2, 页码 255-261出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.193.2.255
关键词
prostanoid receptor; G alpha i-type G protein; T cells; cell migration; allergic inflammation
Prostaglandin (PG)D-2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD, cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD(2). In response to PGD(2), CRTH2 induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells in a G alphai-dependent manner. In addition, CRTH2, but not DP, mediates PGD(2)-dependent cell migration of blood eosinophils and basophils. Thus, PGD(2) is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据