期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 98, 期 2, 页码 615-619出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.021548898
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资金
- NHLBI NIH HHS [HL10344, F32 HL010344, HL49277, R01 HL049277] Funding Source: Medline
- NIGMS NIH HHS [F31 GM020069, GM20069, R01 GM020069] Funding Source: Medline
Adrenomedullin, a recently identified potent vasodilator, is expressed widely and has been suggested to have functions ranging from reproduction to brood pressure regulation. To elucidate these functions and define more precisely sites of Adm expression, we replaced the coding region of the Adm gene in mice with a sequence encoding enhanced green fluorescent protein while leaving the Adm promoter intact. We find that Adm(-/-) embryos die at midgestation with extreme hydrops fetalis and cardiovascular abnormalities, including overdeveloped ventricular trabeculae and underdeveloped arterial walls. These data suggest that genetically determined absence of Adm may be one cause of nonimmune hydrops fetalis in humans.
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