期刊
NEUROREPORT
卷 12, 期 1, 页码 11-15出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200101220-00010
关键词
clozapine; haloperidol; negative symptom; phencyclidine (PCP); social behavior (SB)
Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SE deficit was observed on repeated treatment with methamphetamine for 14 days. The SE deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SE in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SE deficit. NeuroReport 12:11-15 (C) 2001 Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据