期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 2, 页码 235-238出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00642-9
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A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model. (C) 2001 Elsevier Science Ltd. All rights reserved.
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