期刊
NEUROREPORT
卷 12, 期 1, 页码 157-161出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200101220-00039
关键词
basal ganglia; ERPs; error; error negativity; Parkinson's disease
The error negativity (N-e or ERN) is an event-related brain potential component, which is assumed to reflect error detection. Recently it has been hypothesized that the basal ganglia are assumed to play a crucial role in error detection. In the present study we ask whether the N-e is altered in patients with Parkinson's disease (PD), who have an impaired function of the basal ganglia. We recorded the N-e in patients and in matched controls, while they performed different tasks that require a relatively high cognitive control, which is supposed to pose particular problems on PD. The N-e was in fact smaller in the patients than in the controls in all tasks. Our results suggest an impairment of error detection in PD for different types of demanding tasks. This supports the hypothesis that the basal ganglia do play an important role for error detection in action monitoring. NeuroReport 12:157-161 (C) 2001 Lippincott Williams & Wilkins.
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