期刊
BIOCHIMIE
卷 93, 期 11, 页码 1955-1961出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2011.07.008
关键词
mRNA; Structural RNA; Multifunctional RNA; RNA World Hypothesis; Cytoskeleton; VegT mRNA; Nuclear bodies
资金
- NSF [IOS-0904186]
- TAMS
Since the discovery of messenger RNA (mRNA) over half a century ago, the assumption has always been that the only function of mRNA is to make a protein. However, recent studies of prokaryotic and eukaryotic organisms unexpectedly show that some mRNAs may be functionally binary and have additional structural functions that are unrelated to their translation product. These findings imply that some of the phenotypic features of cells and organisms can also be binary, that is, they depend both on the function of a protein and the independent structural function of its mRNA. In this review, we will discuss this concept within the framework of multifunctional RNA molecules and the RNA World Hypothesis. (C) 2011 Elsevier Masson SAS. All rights reserved.
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