期刊
BIOCHIMIE
卷 92, 期 1, 页码 33-40出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2009.10.004
关键词
Biofilm; OMA; Outer membrane; Pel; Matrix
资金
- EST Marie Curie [MEST-CT2005-020278]
- ERA-NET Pathogenomics
- Royal Society
- CNRS
Pseudomonas aeruginosa is an opportunistic pathogen, which causes numerous infections and can adopt a versatile lifestyle. During chronic infection, P. aeruginosa becomes established as a bacterial community known as a biofilm. Biofilm formation results from the production of a matrix mainly comprised of exo-polysaccharides. P. aeruginosa possesses several gene clusters which contribute to the formation of the matrix, including the pet genes. Among the pel genes, pelC encodes an outermembrane protein, which may serve as a transporter of polysaccharide to the bacterial cell surface. Whereas outer membrane proteins usually display an amphipathic P-barrel fold, we show that PelC requires a C-terminal amphipathic a-helix for outer membrane insertion and function. Such a structural feature has only previously been reported for the Wza outer membrane protein of Escherichia coli, and our data suggest that this characteristic may be found in a large family of proteins, particularly outer membrane proteins specialized in polysaccharide transport. (C) 2009 Elsevier Masson SAS. All rights reserved.
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