期刊
BIOCHIMIE
卷 92, 期 6, 页码 692-697出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2010.02.011
关键词
Platelet-activating factor; Sepsis; Anaphylaxis; Inflammation; Lipid mediators
资金
- NIH [K08 HD049699]
- NIH Special Center of Research in ARDS
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [K08HD049699] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL044525, R01HL044525, R01HL091754, T32HL007636, P50HL050153] Funding Source: NIH RePORTER
The platelet-activating factor (PAF) signaling cascade evolved as a component of the repertoire of innate host defenses, but is also an effector pathway in inflammatory and thrombotic diseases. This review focuses on the PAF signaling cascade in systemic inflammatory responses and, specifically, explores its activities in experimental and clinical sepsis and anaphylaxis in the context of the basic biochemistry and biology of signaling via this lipid mediator system. (C) 2010 Elsevier Masson SAS. All rights reserved.
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