期刊
THORACIC AND CARDIOVASCULAR SURGEON
卷 49, 期 1, 页码 35-40出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2001-9917
关键词
cardiac lymphatic obstruction; pulmonary lymphatic obstruction; endothelial injury; lymphedema; pulmonary hypertension
Many thoracic surgical procedures involve excision or destruction of intrathoracic and mediastinal lymphatics. It is widely assumed that the mediastinal lymphatic system is surgically expendable, and that destruction of mediastinal lymphatics has no significant adverse physiological effect. Cardiac lymphatic obstruction may give rise to cardiac lymphedema and impaired cardiac function. Similarly, obstruction of pulmonary lymphatics may result in pulmonary perivascular lymphedema, endothelial injury, and pulmonary artery hypertension. This review summarizes the possible deleterious effects of intrathoracic lymphatic destruction and the benefits of pharmacological and surgical enhancement of active lymph drainage.
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