期刊
BIOCHIMIE
卷 90, 期 8, 页码 1197-1206出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2008.01.015
关键词
DNA; G-quadruplex; single molecule FRET; conformations; hTelo
资金
- Biotechnology and Biological Sciences Research Council [BB/C51444X/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/C51444X/1] Funding Source: Medline
Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter of a proto-oncogene. The findings are discussed with respect to the proposed biological function(s) of such motifs in living cells. (C) 2008 Elsevier Masson SAS. All rights reserved.
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