期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1836, 期 1, 页码 177-185出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2013.04.006
关键词
Galectin; Metastasis; Immune escape; Angiogenesis; Cancer therapy
资金
- Dutch Cancer Society [UM2008-4101, VU2009-4358]
Galectin family members have been shown to exert multiple roles in the context of tumor biology. Several recent findings support a similar multi-faceted role for galectin-9. Galectin-9 expression is frequently altered in cancer as compared to normal tissues. In addition, an increasing amount of evidence suggests that galectin-9 is involved in several aspects of tumor progression, including tumor cell adhesion and survival, immune escape and angiogenesis. Also, galectin-9 shows potential as a prognostic marker and a therapeutic target for several malignancies. In this review we summarize both the established and the emerging roles of galectin-9 in tumor biology and discuss the potential application of galectin-9 in anti-cancer therapy. (C) 2013 Elsevier B.V. All rights reserved.
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