期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1836, 期 1, 页码 42-48出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2013.02.006
关键词
Apoptosis; Marine organisms; Peptides
资金
- National Natural Science Foundation of China [30801453, 81072065, 81273550]
- Special Scientific Research Funds for Central Non-profit Institutes, Yellow Sea Fisheries Research Institutes [20603022012013, 20603022013017]
Apoptosis is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. Targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Peptides from marine organisms have become important sources in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. This primer summarizes several marine peptides, based on their effects on apoptotic signaling pathways, although most of these peptides have not yet been studied in depth for their mechanisms of action. Novel peptides that induce an apoptosis signal pathway are presented in association with their pharmacological properties. (C) 2013 Elsevier B.V. All rights reserved.
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