期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1836, 期 1, 页码 80-89出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2013.01.001
关键词
Adenomatous polyposis coli/APC; Apc mouse model; FAP model; Conditional Apc mutation; Intestinal polyposis; LOH/Apc mouse model
资金
- National Cancer Institute [RO1 CA109220]
- National Center for Research Resources [P20 RR016475]
- National Institute of General Medical Sciences from the National Institutes of Health [P20 GM103418]
Mutation of tumor suppressor gene adenomatous polyposis coil (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations. (C) 2013 Elsevier B.V. All rights reserved.
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