期刊
CELL STRUCTURE AND FUNCTION
卷 26, 期 1, 页码 11-17出版社
JAPAN SOC CELL BIOLOGY
DOI: 10.1247/csf.26.11
关键词
PECAM-1; fluid shear stress; mechanosensing; cell adhesion; cytoskeleton
类别
Endothelial cells are capable of responding to fluid shear stress, but the molecular mechanism for this biological response remains largely unknown. Our studies indicate that the cell-cell adhesion site is a possible site of flow sensing, PECAM-1, a cell adhesion molecule localized to the interendothelial cell adhesion site, is tyrosine-phosphorylated when endothelial cells are exposed to physiological levels of fluid shear stress. This PECAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells.
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