期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1815, 期 2, 页码 224-240出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2011.01.001
关键词
Mucins; Polymorphic epithelial mucins; MUC1 (DF3); MUC4; MUC16 (CA125); Cancer; Breast cancer; Cell survival; Apoptosis
资金
- Department of Defense [BC074639, BC083295, BC09742]
- National Institutes of Health [RO1 CA78590, EDRN UO1 CA111294, RO1 CA133774, RO1 CA131944, P50 CA127297, RO3 CA139285]
- Susan Komen Foundation [KG070826]
Mucins are high molecular weight, multifunctional glycoproteins comprised of two structural classes the large transmembrane mucins and the gel-forming or secreted mucins. The primary function of mucins is to protect and lubricate the luminal surfaces of epithelium-lined ducts in the human body. Recent studies have identified a differential expression of both membrane bound (MUC1, MUC4 and MUC16) and secreted mucins (MUC2, MUC5AC, MUC5B and MUC6) in breast cancer tissues when compared with the non-neoplastic breast tissues. Functional studies have also uncovered many unique roles of mucins during the progression of breast cancer, which include modulation in proliferative, invasive and metastatic potential of tumor cells. Mucins function through many unique domains that can form complex association with various signaling molecules including growth factor receptors and intercellular adhesion molecules. While there is growing information about mucins in various malignancies including breast cancer, no focused review is there on the expression and functional roles of mucins in breast cancer. In this present review, we have discussed the differential expression and functional roles of mucins in breast cancer. The potential of mucins as diagnostic and prognostic markers and as therapeutic targets in breast cancer have also been discussed. (C) 2011 Elsevier B.V. All rights reserved.
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