期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1806, 期 1, 页码 122-130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2010.04.003
关键词
PDGF-D; Cancer; Signaling; Therapy; Nutrition
资金
- National Cancer Institute, NIH [5R01CA131151, 5R01CA083695, 1R01CA132794, 1R01CA101870]
- Department of Defense [W81XWH-08-1-0196]
- University of Texas MD Anderson Cancer Center [5P20-CA101936]
Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring chemopreventive agent such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGFD signaling. (C) 2010 Elsevier B.V. All rights reserved.
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