Molecular mechanics modelling of Pt/nucleotide and Pt/DNA interactions

Applications of molecular mechanics modelling to the study of Pt/nucleotide and Pt/DNA interactions are reviewed. Difficulties associated with modelling the Pt moieties and their interactions with biomolecules are discussed. The use of molecular mechanics to study small molecule Pt/nucleobase and Pt/nucleotide complexes is analysed. Models of Pt/oligonucleotide interactions, used for a variety of purposes, but primarily to aid in the analysis of experimental results or to augment experimental data as in structural studies by NMR spectroscopy, are described. (C) 2001 Elsevier Science B.V. All rights reserved.