期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 49, 期 2, 页码 209-217出版社
HISTOCHEMICAL SOC INC
DOI: 10.1177/002215540104900208
关键词
semicarbazide-sensitive amine oxidase (SSAO); human peripheral tissues; immunohistochemistry; enzymology
类别
Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation.
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