期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1844, 期 9, 页码 1550-1559出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2014.04.014
关键词
Telomere; TPP1; Shelterin; Telomerase; DNA damage; Chromosome stability
资金
- National Institutes of Health [DP2 CA186571, R21 CA169611]
- American Cancer Society [RSG-13-211-01-DMC]
- American Heart Association [11SDB5580010]
Telomeres are nucleoprotein complexes that cap the ends of all linear chromosomes and function to prevent aberrant repair and end-to-end chromosome fusions. In somatic cells, telomere shortening is a natural part of the aging process as it occurs with each round of cell division. In germ and stem cells, however, the enzyme telomerase synthesizes telomere DNA to counter-balance telomere shortening and help maintain cellular proliferation. Of the primary telomere end-binding proteins, TPP1 has recently emerged as a primary contributor in protecting telomere DNA and in recruiting telomerase to the telomere ends. In this review, we summarize the current knowledge regarding the role of TPP1 in telomere maintenance. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据