期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1804, 期 2, 页码 285-297出版社
ELSEVIER
DOI: 10.1016/j.bbapap.2009.10.011
关键词
Superoxide; Neelaredoxin; Desulfoferrodoxin; Iron
资金
- Fundacao para a Ciencia e Tecnologia, Portugal
Superoxide anion is among the deleterious reactive oxygen species, towards which all organisms have specialized detoxifying enzymes. For quite a long time, superoxide elimination was thought to occur through its dismutation, catalyzed by Fe, Cu, and Mn or, as more recently discovered, by Ni-containing enzymes. However, during the last decade, a novel type of enzyme was established that eliminates superoxide through its reduction: the superoxide reductases, which are spread among anaerobic and facultative microorganisms, from the three life kingdoms. These enzymes share the same unique catalytic site, an iron ion bound to four histidines and a cysteine that, in its reduced form, reacts with superoxide anion with a diffusion-limited second order rate constant of similar to 10(9) M-1 s(-1). In this review, the properties of these enzymes will be thoroughly discussed. (C) 2009 Elsevier B.V. All rights reserved.
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