期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1804, 期 5, 页码 1049-1063出版社
ELSEVIER
DOI: 10.1016/j.bbapap.2009.06.012
关键词
DNA polymerase proofreading; DNA replication fidelity; Mutator and antimutator DNA polymerases; Proofreading pathway; Active site switching; Okazaki fragment maturation
资金
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Alberta Heritage Foundation for Medical Research (AHFMR)
DNA polymerase proofreading is a spell-checking activity that enables DNA polymerases to remove newly made nucleotide incorporation errors from the primer terminus before further primer extension and also prevents translesion synthesis. DNA polymerase proofreading improves replication fidelity similar to 100-fold, which is required by many organisms to prevent unacceptably high, life threatening mutation loads. DNA polymerase proofreading has been studied by geneticists and biochemists for >35 years. A historical perspective and the basic features of DNA polymerase proofreading are described here, but the goal of this review is to present recent advances in the elucidation of the proofreading pathway and to describe roles of DNA polymerase proofreading beyond mismatch correction that are also important for maintaining genome stability. (C) 2009 Elsevier B.V. All rights reserved.
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