期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1804, 期 8, 页码 1635-1644出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2009.11.010
关键词
Sirtuins; Inhibitor; NAD(+); Metabolism; Selectivity
Accumulating evidence has indicated the importance of sirtuins (class III histone deacetylases) in various biological processes. Their potential roles in metabolic and neurodegenerative diseases have encouraged scientists to seek potent and selective sirtuin inhibitors to investigate their biological functions with a view to eventual new therapeutic treatments. This article surveys current knowledge of sirtuin inhibitors including those discovered via high-throughput screening (HST) or via mechanism-based drug design from synthetic or natural sources. Their inhibitory affinity, selectivities, and possible inhibition mechanisms are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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