期刊
AIDS
卷 15, 期 -, 页码 S22-S27出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200102002-00005
关键词
interleukin-2; cytokine; immune reconstitution; HIV
资金
- NCI NIH HHS [CA-70080] Funding Source: Medline
- NCRR NIH HHS [RR-00865] Funding Source: Medline
- NIAID NIH HHS [AI-28697, AI-27660] Funding Source: Medline
Interleukin-2 (IL-2) is a secretory cytokine produced by activated T cells that stimulates T cells, B cells, and natural killer cells to proliferate and release cytokines. In addition, IL-2 slows apoptosis of HIV-infected cells. Clinical studies have demonstrated that exogenous human recombinant IL-2 can be safely administered concurrently with potent antiretroviral therapy to HIV-infected patients. It was further demonstrated that recombinant human IL-2 therapy produces sustained increases in CD4+ cell number and function in patients with both early and late HIV disease. Further evaluation of the clinical efficacy of IL-2 in HIV-infected patients is expected to provide important information on the utility of recombinant human IL-2 in HIV disease. (C) 2001 Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据