期刊
BRITISH JOURNAL OF DERMATOLOGY
卷 144, 期 2, 页码 384-386出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2133.2001.04033.x
关键词
extragenital Bowen's disease; human papillomavirus type 58; in situ hybridization; polymerase chain reaction; Southern blot hybridization
类别
Human papillomavirus (HPV) can be detected in skin lesions of Bowen's disease, particularly on the fingers, and its genotype is associated with mucosal/genital types of HPV. We report herein an 85-year-old woman who had HPV-associated Bowen's disease on her elbow HPV-58 DNA was detected in the lesion by polymerase chain reaction with restriction fragment length polymorphism and by Southern blot hybridization. In situ hybridization revealed numerous hybrid cells in the nuclei of the upper epidermis and stratum corneum of Bowen's disease. A high-risk type of mucosal HPV-58 DNA is associated with Bowen's disease in this case, suggesting that HPV-related Bowen's disease is not always restricted to genital or finger lesions.
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