期刊
PURE AND APPLIED CHEMISTRY
卷 73, 期 2, 页码 227-232出版社
INT UNION PURE APPLIED CHEMISTRY
DOI: 10.1351/pac200173020227
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RuCl2(phosphine)(2)(1,2-diamine) complexes, coupled with an alkaline base in 2-propanol, allows for preferential hydrogenation of a C=O function over coexisting conjugated or nonconjugated C=C linkages, a nitro group, halogen atoms, and various heterocycles. The functional group selectivity is based on the novel metal-ligand bifunctional mechanism. The use of appropriate chiral diphosphines and diamines results in rapid and productive asymmetric hydrogenation of a range of aromatic, hetero-aromatic, and olefinic ketones. The versatility of this method is manifested by the asymmetric synthesis of various biologically significant chiral compounds.
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