期刊
AMERICAN JOURNAL OF PSYCHIATRY
卷 158, 期 2, 页码 305-308出版社
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.158.2.305
关键词
-
类别
资金
- NIMH NIH HHS [MH-01244, MH-35636, MH-40695] Funding Source: Medline
Objective: The antidepressant action of ECT may be related to its anticonvulsant properties. Positron emission tomography (PET) studies of regional cerebral metabolic rate for glucose were used to test this hypothesis. Method: Ten patients with major depression were studied with PET before and approximately 5 days after a course of bilateral ECT. Statistical parametric mapping was used to identify regions of decreased cerebral glucose metabolism. Results: Widespread regions of decreased regional cerebral glucose metabolism were identified after ECT, especially in the frontal and parietal cortex, anterior and posterior cingulate gyrus, and left temporal cortex. A region-of-interest analysis similarly indicated post-ECT reductions in regional cerebral glucose metabolism. Conclusions: ECT reduces neuronal activity in selected cortical regions, a potential anticonvulsant and antidepressant effect.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据