Oxygenation of amyloid beta-peptide (1-40) by copper(II) complex and hydrogen peroxide system

Electrospray mass-spectrometry (ESI-Mass) has revealed that some copper(II) compounds, but not others, catalyze oxygenation of amyloid beta -peptide (1-40). undoubtedly at methionine sulfur atom, in the presence of hydrogen peroxide: this will give an important information to elucidate the role of copper ion in the brain to induce neurodegenerative disorders, such as Alzheimer's and Prion diseases. (C) 2001 Elsevier Science B.V. All rights reserved.