期刊
MOLECULAR BIOLOGY OF THE CELL
卷 12, 期 2, 页码 449-462出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.12.2.449
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- NHLBI NIH HHS [R01 HL049376, HL-49376] Funding Source: Medline
- NINDS NIH HHS [NS-28121, P01 NS028121] Funding Source: Medline
In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type I and type 2 All receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.
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