期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1833, 期 11, 页码 2392-2402出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2013.02.021
关键词
Protein translocation; Protein targeting; Protein biogenesis; Ribosome; Signal recognition particle; Translocon
资金
- Biology and Biotechnology Research Council (BBSRC)
- Biotechnology and Biological Sciences Research Council [BB/H007202/1] Funding Source: researchfish
- BBSRC [BB/H007202/1] Funding Source: UKRI
Co-translational protein targeting to the endoplasmic reticulum (ER), represents an evolutionary-conserved mechanism to target proteins into the secretory pathway. In this targeting pathway proteins possessing signal sequences are recognised at the ribosome by the signal recognition particle while they are still undergoing synthesis. This triggers their delivery to the ER protein translocation channel, where they are directly translocated into the ER. Here we review the current understanding of this translocation pathway and how molecular details obtained in the related bacterial system have provided insight into the mechanism of targeting and translocation. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. (c) 2013 Published by Elsevier B.V.
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