Calculation of the hydrophobicity of platinum drugs

Models of the hydrophobicity of platinum drugs based on exposed surface areas of polar and nonpolar atoms are presented. For a total of 24 log P-oct data, the best model resulted in a standard deviation of 0.35 over a range of more than 4 log units, with regression coefficients in broad agreement with previous models of log P-oct for organic molecules. This model is used to compare log P-oct to cell uptake for five platinum drugs and hence to establish an exponential relation between these parameters.