期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 25, 期 2, 页码 283-287出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1111/j.1530-0277.2001.tb02210.x
关键词
prenatal alcohol exposure; pregnancy risk; fetal alcohol syndrome; fetal alcohol effects; screening
资金
- NIAAA NIH HHS [R37 AA01455-01-25] Funding Source: Medline
Background: The incidence of Fetal Alcohol Syndrome (FAS) has been estimated at 1 to 3 per 1000 live births. Fetal Alcohol Spectrum Disorders (FASD) (which include FAS) are estimated to occur in about 1 in 100 births. Cessation of drinking during pregnancy can improve the outcome even if the unborn child is already affected. For individuals born with FASD, an early diagnosis appears to be a protective factor against secondary disabilities. A quick screening tool to identify newborn children at risk has been elusive. Methods: A simple descriptive presentation is offered that shows where 36 individuals with FASD were found from among the many patterns and amounts of prenatal alcohol use that were reported by a sample of 1439 pregnant women whose offspring were later examined within the first 7 years of life. Results: Individuals with FASD (i.e., those with FAS, fetal alcohol effects, alcohol-related neurodevelopmental disorder)were found within two aggregates of alcohol scores that together recommend a set of three to four alcohol questions. Within this derivation sample, one scoring of the questions yields almost 78% sensitivity and 97% specificity for FASD. Another scoring of the same instrument yields 100% sensitivity with 90% specificity. Conclusions: These new data may facilitate early identification of offspring who may be most in need of early intervention, namely those born with FASD.
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