期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1833, 期 12, 页码 3346-3354出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2013.10.007
关键词
BAG3; c-Jun; Growth inhibition; JunD
资金
- National Natural Science Foundation of China [31170727, 31170745, 81271292]
- Program for LNET [LJQ2011083]
BAG3 plays a regulatory role in a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, epithelial-mesenchymal transition (EMT), autophagy activation, and virus infection. The AP-1 transcription factors are implicated in a variety of important biological processes including cell differentiation, proliferation, apoptosis and oncogenesis. Recently, it has been reported that AP-1 protein c-Jun inhibits autophagy and enhances apoptotic cell death mediated by starvation. However, the molecular mechanisms remain unclear. For the first time, the current study demonstrated that serum starvation downregulated BAG3 at the transcriptional level via c-Jun. In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by BAG3. (C) 2013 Elsevier B.V. All rights reserved.
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