期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1823, 期 9, 页码 1451-1458出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2012.06.014
关键词
NGAL; Siderocalin; UTI; Acute Kidney Injury; Catechol; Enterochelin
资金
- NIDDK NIH HHS [R01 DK073462, P50 DK096418, R21 DK091729] Funding Source: Medline
Kidney damage induces the expression of a myriad of proteins in the serum and in the urine. The function of these proteins in the sequence of damage and repair is now being studied in genetic models and by novel imaging techniques. One of the most intensely expressed proteins is lipocalin2, also called NGAL or Siderocalin. While this protein has been best studied by clinical scientists, only a few labs study its underlying metabolism and function in tissue damage. Structure-function studies, imaging studies and clinical studies have revealed that NGAL-Siderocalin is an endogenous antimicrobial with iron scavenging activity. This review discusses the iron problem of kidney damage, the tight linkage between kidney damage and NGAL-Siderocalin expression and the potential roles that NGAL-Siderocalin may serve in the defense of the urogenital system. This article is part of a Special Issue entitled: Cell Biology of Metals. (C) 2012 Published by Elsevier B.V.
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