期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1823, 期 4, 页码 850-860出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2012.01.004
关键词
FGF; FGFR; Receptor tyrosine kinase; Signalling; Cancer; Cancer therapy
资金
- MRC
- Cancer Research U.K.
- MRC [G0802141] Funding Source: UKRI
- Cancer Research UK [15151] Funding Source: researchfish
- Medical Research Council [G0802141] Funding Source: researchfish
In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated signalling in carcinogenesis are considered and relevant underlying mechanisms highlighted. FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy. Here we review the accumulating reports that revealed the association of FGF/FGFRs to various types of cancer at a genetic level, along with in vitro and in vivo evidences available so far, which indicates the functional involvement of FGF signalling in tumour formation and progression. An increasing number of drugs against the FGF pathways is currently in clinical testing. We will discuss the strategies for future FGF research in cancer and translational approaches. (c) 2012 Elsevier B.V. All rights reserved.
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