期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1813, 期 6, 页码 1137-1143出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2011.01.033
关键词
Prohibitin; Therapeutic; Cancer; Inflammation; Obesity; Diabetes
资金
- The Broad Foundation [IBD-0226R]
- National Institutes of Health [R01-DK06411, K01-DK085222]
Prohibitin 1 (PHB1), a pleiotropic protein in the cell, has been implicated in the regulation of proliferation, apoptosis, transcription, mitochondrial protein folding, and as a cell-surface receptor. This diverse array of functions of PHB1 is attributed to the cell type studied and its subcellular localization. This review discusses recent data that indicate a diverse role of PHB1 in disease pathogenesis and suggest that targeting PHB1 may be a potential therapeutic option for treatment of diseases including cancer, inflammatory bowel disease, insulin resistance/type 2 diabetes, and obesity. These diseases are associated with increased oxidative stress and mitochondrial dysfunction and therefore, the role of PHB1 in both responses will also be discussed. (C) 2011 Elsevier B.V. All rights reserved.
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