期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 213, 期 1-2, 页码 25-29出版社
ELSEVIER
DOI: 10.1016/S0378-5173(00)00617-7
关键词
solubilization; rapamycin; solubility; cosolvent; hydrotrope; hydrotropy
The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic(> 1000-fold) increase in the aqueous solubility of rapamycin. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据