期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1803, 期 6, 页码 706-714出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2009.11.007
关键词
Protein import; Mitochondria; Outer membrane; Chaperone; Translocator; Receptor
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Grants-in-Aid for Scientific Research [19058005] Funding Source: KAKEN
Mitochondria are surrounded by two biological membranes. The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB/SAM complexes for protein translocation across and/or insertion into the outer membrane. The TOM40 complex functions as an entry gate for most mitochondrial proteins, and the TOB/SAM complex as a specialized insertion machinery for beta-barrel membrane proteins In order to handle loosely folded or unfolded precursor polypepndes, those translocators cooperate with chaperones in the cytosol and intermembrane space, and also exhibit chaperone-like functions on their own Several a-helical membrane proteins take 'non-standard' routes to be inserted into the outer membrane. Here we review the current view on a remarkable variety of mechanisms of protein transport taking place at the mitochondrial outer membrane (C) 2009 Elsevier B.V All rights reserved
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