期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1803, 期 1, 页码 72-94出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2009.08.006
关键词
Zinc-binding group; Mechanism-based inhibitor; MMP
资金
- University of California, San Diego
- National Institutes of Health [R01 HL00049-01, 5 T32 HL007444-27]
- American Heart Association [0970028N]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007444] Funding Source: NIH RePORTER
This short review highlights some recent advances in matrix metalloproteinase inhibitor (MMPi) design and development. Three distinct approaches to improved MMP inhibition are discussed: (1) the identification and investigation of novel zinc-binding groups (ZBGs), (2) the study of non-zinc-binding MMPi, and (3) mechanism-based MMPi that form covalent adducts with the protein. Each of these strategies is discussed and their respective advantages and remaining challenges are highlighted. The studies discussed here bode well for the development of ever more selective, potent, and well-tolerated MMPi for treating several important disease pathologies. (C) 2009 Elsevier B.V. All rights reserved.
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