期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1793, 期 2, 页码 223-230出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2008.11.001
关键词
TRPC; Store-operated Ca2+ entry; Type II IP3 receptor; STIM1; Orai1
资金
- M.E.C.-FEDER [BFU2007-60104/BFI]
Store-operated calcium entry (SOCE) is a major mechanism for Ca2+ influx. Since SOCE was first proposed two decades ago many techniques have been used in attempting to identify the nature of store-operated Ca2+ (SOC) channels. The first identified and best-characterised store-operated current is I-CRAC, but a number of other currents activated by Ca2+ store depletion have also been described. TRPC proteins have long been proposed as SOC channel candidates; however, whether any of the TRPCs function as SOC channels remains controversial. This review attempts to provide an overview of the arguments in favour and against the role of TRPC proteins in the store-operated mechanisms of agonist-activated Ca2+ entry. (C) 2008 Elsevier B.V. All rights reserved.
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